Abstract
Objectives: Aortic mural angiogenesis is a key pathologic feature of AAA disease. We previously reported that VEGF-receptor 2 expression correlated with experimental AAA progression. This study evaluated the influence of anti-VEGF-A monoclonal antibody (mAb) therapy on AAA formation and progression in the porcine pancreatic elastase (PPE) infusion model in C57Bl/6J mice. Methods: PPE-infused mice were given anti-VEGF-A neutralizing mAb or control mAb. Aortic aneurysm progression was evaluated via serial transabdominal in vivo ultrasonography and histology at sacrifice. Results: In control mAb-treated mice, persistent and significant aortic enlargement was noted beginning the third day following PPE infusion. Anti-VEGF-A mAb
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