Abstract
It is known that c-kit + cells are increased in heart after infarction. The exact origins of the cardiac c-kit + cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit + cells. Our data show that the number of c-kit + cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathway.
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