Abstract
Induction of angiogenesis in the uterine decidua is a key event in peri-implantation uterine differentiation and blastocyst implantation. VEGFR-2 is expressed on vessels in the periphery (secondary decidual zone), and to a lesser extent, in the area surrounding the embryo (primary decidual zone). In contrast, VEGFR-3 expression is restricted to vessels in the primary decidual zone. Given the distinct expression patterns, we hypothesized that VEGFR-2 and VEGFR-3 make unique contributions to peri-implantation uterine angiogenesis.
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