Abstract
Vascular endothelial growth factor (VEGF) in neurodevelopment and regeneration: VEGF is a well-known factor that promotes vascularization and angiogenesis. Besides this it participates in the pathogenesis of several diseases, such as colorectal carcinoma, lung cancer or diabetic retinopathy. Within the last decade, VEGF has been successfully integrated into the treatment of such diseases, for example as a therapy for colorectal cancer with the VEGF-receptor (VEGFR)-inhibitor axitinib. VEGF effects in those diseases are primarily exerted via neovascularization and angiogenesis, which are mainly initiated by hypoxia to support tumor growth. VEGF is expressed by a high number of different cells, amongst others its expression was confirmed in different tumor cell-lines as well as in common, physiological cells. A well known initiator of VEGF (over-) expression is the hypoxia inducible factor (HIF), which is a transcriptional factor, leading to an enhanced VEGF expression.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
