Abstract
Special attention is given to MS bearing in mind its high prevalence in the general population (up to 14-24 %) which is twice the prevalence of diabetes. The study included 50 patients with MS at the age of 25 to 61 years. The group of comparison contained 16 healthy individuals aged 45,3±2,3 years. To evaluate the response of microvascular tone, the wavelet analysis of fluctuations of skin temperature during limb cooling was used. Vascular endothelial growth factor (VEGF) served as a biochemical marker of endothelial dysfunction. Heart rate variability was evaluated in all patients. It was shown that patients with MS were significantly different in terms of all metabolic parameters; their VEGF levels were much higher than in the comparison group. Disturbances of vasodilation identified in the functional cold test in patients with MS confirm the relationship between abnormal vascular reactivity and endothelial dysfunction markers. The cardiointervalographic examination of MS patients revealed typical manifestations of autonomous cardiac neuropathy.
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