Abstract
VDR gene polymorphism and trace elements in Thai postmenopausal women with risk of osteoporosis: Cross -sectional study
Highlights
Osteoporosis progresses without any symptoms until a bone fracture occurs
bone mineral density (BMD) was significantly negatively correlated with alkaline phosphatase (ALP) and Ca (r = −0.239 and −0.673) and positively correlated with Mg and Zn (r = 0.327 and 0.383)
There are various genes involved in osteoclast proliferation, which are associated with bone mass reduction or osteoporotic fractures, including the vitamin D receptor (VDR), estrogen receptor, and collagen type I alpha-I genes (Stewart and Ralston, 2000)
Summary
Osteoporosis progresses without any symptoms until a bone fracture occurs. Osteoporotic fractures are a common problem in public health control and intervention, which relate to increasing immobility and mortality, affecting quality of life, and high economic impact due to extended hospital stay (Black and Rosen, 2016; Kawalkar, 2015). There are various genes involved in osteoclast proliferation, which are associated with bone mass reduction or osteoporotic fractures, including the vitamin D receptor (VDR), estrogen receptor, and collagen type I alpha-I genes (Stewart and Ralston, 2000). The variations VDR gene polymorphisms have been reported, and VDR genotypes are associated with bone diseases, including multiple sclerosis, osteoporosis, vitamin D-dependent rickets type II (Cantorna and Mahon, 2004; Jiang et al, 2020; Valdivielso and Fernandez, 2006), and essential hypertension (Banjabi et al, 2020).
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