Abstract
Vav Proteins' Role in Skin Cancer
Highlights
The most common form of skin cancer, squamous cell carcinoma usually isn’t deadly
Researchers believe a family of compounds called GDP/GDT exchange factors (GEFs) are critical to Rho GTPase activity in tumor development and maintenance; because there are so many GEFs, determining which ones are essential and what their exact roles are have been open questions
The researchers describe studies showing that GEFs of the Vav subfamily play important roles in the development of skin cancer tumors in mice
Summary
The most common form of skin cancer, squamous cell carcinoma usually isn’t deadly. neither is it benign; in some cases it can be aggressive and spread to other organs. The researchers describe studies showing that GEFs of the Vav subfamily play important roles in the development of skin cancer tumors in mice. The scientists worked with knockout mice deficient for Vav2 and Vav3 and with tissue cultures that were deficient for the two proteins.
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