Abstract
Vaspin is a novel adipocytokine with insulin-sensitizing effects. However, it is not known whether a correlation exists between human vaspin serum levels and markers of insulin sensitivity and glucose or lipid metabolism. To determine whether there is an association between serum vaspin levels (a novel adipocytokine with insulin-sensitizing effects), type 2 diabetes mellitus (T2D) and atherosclerosis. The study included 40 patients with T2D divided into 20 without hypertension (group 1), 20 with hypertension (group 2) and 15 age-matched and sex-matched healthy control participants (group 3). The serum vaspin level was determined by enzyme-linked immunosorbent assay. Its level was compared between both diabetic patients and controls, and between diabetic patients without hypertension and those with hypertension. All participants were subjected to an imaging procedure in the form of carotid Doppler to measure the intima — media thickness as an early marker of atherosclerosis. The serum vaspin level was significantly higher in diabetic patients compared with control participants. There was significant increase in the left carotid intima–media thickness in diabetic patients with hypertension and without hypertension compared with control participants. There was a significant positive correlation between the serum vaspin level and the BMI in diabetic patients with hypertension, a significant negative correlation between the serum vaspin level and the duration of diabetes and a significant negative correlation between the serum vaspin level and HDL in diabetic patients without hypertension. There was a significantly high level of serum vaspin in T2D patients. Serum vaspin was shown to be significantly lower in T2D patients with a longer duration of illness. An increased carotid intima–media thickness in diabetic patients was not related to the vaspin level, denoting an underlying combining factor for atherosclerosis in diabetic patients other than vaspin.
Highlights
Diabetes mellitus is a major risk factor for atherosclerosis [1]
We found a statistically significant negative correlation between serum vaspin levels and diabetes duration in all cases (r = -0.330, P = 0.037).This was in agreement with the study by Feng et al [17], who found that patients with a longer diabetes duration had significantly lower serum vaspin levels than those with a shorter duration of diabetes, and he explained this by the fact that poor glucose control and insulin resistance might affect the levels of vaspin independently, with worsening of diabetes
The results of the present study demonstrated significantly high levels of serum vaspin in type 2 diabetes mellitus (T2D) patients with and without hypertension compared with control participants, but there was no statistically significant difference in the serum vaspin levels between diabetic patients with hypertension and diabetic patients without hypertension
Summary
Diabetes mellitus is a major risk factor for atherosclerosis [1]. The comparison of the serum vaspin level between T2D patients with hypertension and without hypertension has not been investigated previously. The present study, investigated the serum vaspin level between T2D patients with hypertension and without hypertension and assessed the relation between the serum vaspin level and the carotid intima atherosclerotic media thickness, BMI and other risk factors. Vaspin is a novel adipocytokine with insulin-sensitizing effects. It is not known whether a correlation exists between human vaspin serum levels and markers of insulin sensitivity and glucose or lipid metabolism. Aim of the work To determine whether there is an association between serum vaspin levels (a novel adipocytokine with insulin-sensitizing effects), type 2 diabetes mellitus (T2D) and atherosclerosis. All participants were subjected to an imaging procedure in the form of carotid Doppler to measure the intima — media thickness as an early marker of atherosclerosis
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