Abstract
The vasorelaxant effects of the atriopeptins, AP-(103–126) and AP-(103–123) were compared in human internal mammary artery (IMA) rings which had been contracted with norepinephrine. AP-(103–126) completely relaxed the IMA with an IC 50 within the physiologically relevant range (15 nM). However, relaxation with AP-(103–123) was greatly reduced compared to AP-(103–126), with complete relaxation observed in only half of the vessels tested and only at concentrations of 10–50 μM. These results indicate that the atriopeptin (AP) receptor in human arteries may be more similar to the AP receptor in rabbit rather than rat arteries.
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