Abstract
1. 1. Twelve adult pygmy goats were used to investigate the mechanism of vasopressin (VP) induced hyperglycaemia. 2. 2. VP (0.4μg/kg or 0.75μg/kg body weight) injected i.p. produced a long lasting hyperglycaemia. 3. 3. This hyperglycaemia was partly reversed by α-adrenergic antagonists with an affinity to α 1- and α 2-adrenergic receptors (phentolamine) or to α 2-adrenergic receptors (yohimbine). An α 1adrenergic agonist (xylometazoline) produced a short-term hyperglycaemia. 4. 4. The ganglion blocking agent hexamethonium also reversed VP's hyperglycaemic effect. 5. 5. It is concluded that VP's hyperglycaemic effect in pygmy goats is due to an increase in sympathetic outflow and not to a direct action on the liver.
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