Abstract
Mortality from cardiovascular abnormalities is almost three times more prevalent in the diabetic population than that in the general population. Psidium guajave has been used traditionally for a long time as a medicinal herb to cure diabetes. Endothelial dependent vasorelaxation effect of Psidium guajave extract on normal aortic rings was observed. This study was designed to investigate the endothelium and nitric oxide roles inPGE-induced vasorelaxation in diabetic rat vessel. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Eight weeks later, superior mesenteric arteries of non-diabetic and diabetic groups were isolated and perfused according to the McGregor method. Prepared vascular beds were constricted with phenylephrine to induce 70% - 75% of maximal constriction. Psidium guajave extract at concentrations of 0.1 to 4 mg/100ml added to the medium and perfusion pressure was recorded. Baseline perfusion pressure of diabetic group was significantly higher than non-diabetic rats in both intact and denuded endothelium. Psidium guajave extract caused a significantly dose depended decrease in perfusion pressure in non-diabetic and diabetic groups in both intact and denuded endothelium. In the presence of N (ω)-nitro-L-arginine methyl ester, Psidium guajave ex-tractinduced relaxation in intact mesenteric beds of non-diabetic and diabetic animals was not suppressed. From the results of this study, it may be concluded that vasorelaxatory effect of Psidium guajave extract is not mediated by endothelium and nitric oxide in both diabetic and non-diabetic vessel and supports the use of the plant’s leaves as a natural, adjunct phytomedicine in the management of diabetes vessel complications.
Highlights
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in spite of significant achievement made over the past decades in the diagnosis and treatment of these conditions [1,2]
We showed that the administration of Psidium guajave Linn extract (PGE) in diabetic rats caused Ca/Mg ratio, plasma glucose, lipid profiles to return to the normal levels, and was shown to decrease alteration in vascular reactivity to vasoconstrictor agents [9]
The results of the present study indicate that the vasorelaxatory effect of Psidium guajave leaves extract (PGE) in nonnon diabeticl intact endothelium non diabetic intact endothelium+L-NAME
Summary
Cardiovascular disorders continue to constitute major causes of morbidity and mortality in spite of significant achievement made over the past decades in the diagnosis and treatment of these conditions [1,2]. The etiology of vascular disorders in diabetes has not completely been understood, it is suggested that the high incidence of vascular atherosclerosis and poor control of hyperglycemia appear to play a significant role in the development of cardiovascular disease in diabetes OPEN ACCESS. In vivo studies demonstrated that hyperglycemic spikes induce, in both diabetic and normal subjects, an endothelial dysfunction [2,7]. This effect of hyperglycemia is probably linked with a reduced production/bioavailability of nitric oxide (NO), since hyperglycemia-induced endothelial dysfunction is counterbalanced by arginine [2]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
