Abstract
The effects of five diphenylalkanolamine derivatives, including YS 3635, YS 3636, YS 3632, YS 3623 and YS 3423, on the coronary and hindquarter vascular beds in anesthetized dogs were studied and compared with those of glyceryl trinitrate and papaverine. These five derivatives in doses of 62.5 to 1000μg i.a. reduced coronary and hindquarter vascular resistances, and the effects were in the following order : YS 3423>YS 3623> papaverine>YS 3632>YS 3635>YS 3636 in the coronary, and YS 3423> papaverine>YS 3623>YS 3635>YS 3632>YS 3636 in the hindquarter vascular beds. Three derivatives, YS 3423, YS 3623 and YS 3635 having a relatively potent vasodilating effect were further examined. These compounds, 1 mg/kg i.v., also showed an increase in coronary and hindquarter blood flows, concomitantly with a transient hypotension, sustained decrease in heart rate and increase in cardiac output. The vasodilating effect of the diphenylalkanolamine derivatives studied appears to show a direct and non-specific effects on the peripheral blood vessels as is the case of glyceryl trinitrate or papaverine.
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