Abstract
Thrombin was infused into a canine femoral artery. At low concentrations vasodilatation occurred. At high concentrations the vasodilatation was followed by intravascular coagulation. Heparinization of the animal or diisopropylfluorophosphate treatment of the thrombin inhibited both the vasodilating and procoagulant activity. Tissue thromboplastin had similar effects on femoral vascular resistance. Heparinization of the animal inhibited the procoagulant but not the vasodilating activity. In thrombin, but not in tissue thromboplastin, the vasodilating and procoagulant activities are correlated.
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