Abstract
In this work we studied the responses and receptors involved in the effects of intra-arterial 5-hydroxytryptamine (5-HT) in the in situ autoperfused hindquarters of spontaneously hypertensive rats (SHR). Intra-arterial administration of the highest doses (50–1,000 ng/kg) produced a vasoconstrictor effect that was inhibited by ritanserin (a selective 5-HT<sub>2</sub> receptor antagonist), SB 206553 (a selective 5-HT<sub>2B/2C</sub> receptor antagonist) and spiperone (a nonspecific 5-HT<sub>1/2A</sub> receptor antagonist), and was mimicked by α-methyl-5-HT (a selective 5-HT<sub>2</sub> receptor agonist) and m-CPP (a selective 5-HT<sub>2C</sub> receptor agonist), but not by the intra-arterial administration of BW 723C86, a selective 5HT<sub>2B</sub> receptor agonist. SB 206553 and spiperone inhibited α-methyl-5HT-induced vasoconstriction in the hindquarters of SHR. Our data suggest that the vasoconstrictor response induced by 5-HT in the autoperfused hindquarters of SHR is mainly mediated by the activation of 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> receptors.
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