Vasoconstrictor Properties in Blood of Hypertensive Dogs

Abstract

Experimental arterial hypertension has been induced in dogs by means of two different methods. In a series of dogs, the 4 moderator nerves (2 aortic and 2 carotid sinus nerves) were cut: both carotid sinuses were completely excised, one cervical aortic-sympathetic-vagus nerve was cut and out of the other aortic-sympathetic-vagus nerve, the aortic and sympathetic fibers were dissected and cut, leaving only a small bunch of vagal fibers sufficient to avoid the accidents of bilateral cervical vagotomy. This technic induces a permanent high blood pressure up to 320 mm Hg for several months. In another group of dogs, chronic arterial hypertension was induced by the permanent compression of the renal arteries, according to Goldblatt's technic.In order to test the presence of vasopressor substances in the blood of these dogs suffering from chronic hypertension, the following technic was used: In a normal dog, anesthetized with chloralosane and sensitized to vasopressor substances by means of cocaine injection, t...