Vasoactive peptide and obstruction sleep apnea syndrome

Abstract

Vasoactive peptide are the material foundation which constitute the circulatory system self-stability adjustment. They are a kind of low molecular weight peptide that regulate the vasodilative and vasoconstrictive function and maintain the vascular tone through the way of autocrine and (or) paracrine. There are dynamic equilibtium in the excretion and activity betwccn vasoconstrictive peptides and vasodilative peptides. The complcx positive feedback or negative feedback exists in different vasoactive peptides, which forms a network of regulation of vascular tone. Their balance disorders can lead to coronary heart disease, hypertension,etc. Obstruction sleep apnea syndrome (OSAS) is a systemic disease, which can cause severe damage to multiple organ. Endothelin-Ⅰ, angiotensin Ⅱ , atrial natriuretic peptide and brain natriuretic peptide, calcitonin gene related peptide are currently found the major vasoactive peptides, vasoconstrictive peptides and vasodilative peptides, imbalances might be OSAS patients disease of heart and head blood-vessel foundation, but its mechanism has not quite clear and controversial up to now, as involving ischemia, endocrine and neuromodulation abnormal, inflammation,oxidative stress and so on many kinds of the pathologic process, OSAS may exist complex pathogenic factors. This article sum up the research of the major vasoactivc peptide and OSAS in order to realize their relationship. Key words: Obstructive sleep apnea syndrome; Endothelin-1; Angiotensin Ⅱ ; Brain natrinretic peptide; Calcitonin gene related peptide