Abstract
The effect of vasoactive intestinal peptide (VIP) was studied on the release of somatostatin (SRIF) from slices of several regions of the rat brain in vitro. VIP induced a dose-dependent inhibition of SRIF release from mediobasal hypothalamic slices but did not interfere with SRIF release from preoptic area, amygdala or cortex. VIP Inhibition had an apparent affinity: K d = 6.8 ± 3.9 × 10 −11 M. Secretin has a similar effect but at 600-fold higher concentrations (K d secretin = 4.2 ± 0.6 × 10 −8 M). Glucagon was ineffective in concentrations ranging from 10 −10 M to 10 −7 M. The data are consistent with a role of VIP in the hypothalamic control of growth hormone secretion.
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