Vaso-Pressor Action of Extracts of Plasma of Normal Dogs and Dogs with Experimentally Produced Hypertension

Abstract

ConclusionHypertension produced in dogs by means of compression of the renal artery has not been shown by the method employed to be caused by liberation of pressor substances into the blood stream which act directly on the peripheral blood vessels to cause vaso-constriction. Nor is the known pressor secretion of the pituitary gland present in amounts large enough to be detected by the method employed, in the blood of animals with hypertension. These conclusions are based on the following evidence: 1. Alcoholic extracts of plasma of dogs with hypertension when injected into anesthetized cats raises the cat's arterial pressure no more effectively than extracts from plasma of normal animals. 2. Removal of the hypophysis in animals with experimental hypertension does not alter the character of the pressor response to extracts of plasma.