Vascularity and Tumor Size are Significant Predictors for Recurrence after Resection of a Pancreatic Neuroendocrine Tumor.

Abstract

It is difficult to identify patients at high risk of recurrence after pancreatectomy for pancreatic neuroendocrine tumor (PNET) using only the grading classification, especially the G2 category, which includes both benign and low- and high-grade malignant tumors. Forty-one patients with PNET who underwent pancreatectomy were enrolled in this study. We defined the computed tomography (CT) ratio as the CT value of the tumor divided by that of non-tumorous pancreatic parenchyma using the late arterial phase dynamic CT. The optimal cut-off values for CT ratio and tumor size were determined using p-values that were calculated using the log-rank test. The optimal cut-off values of CT ratio and tumor size for dividing patients into groups according to the greatest difference in disease-free survival (DFS) were 0.85 (p<0.001) and 3.0cm (p<0.001), respectively. In analysis using Spearman's correlation coefficient, CT ratio (p=0.007) and tumor size (p=0.003) were individually associated with the Ki-67 proliferative index. Cox proportional hazard analysis identified that a CT ratio <0.85 (n=10, p=0.006) and tumor size≥3.0cm (n=13, p=0.023) were independent prognostic factors associated with DFS. All patients in the CT ratio≥0.85 and tumor size<3.0cm group (n=23, including seven patients with G2 disease) did not develop recurrence after surgery. On the other hand, 5-year DFS in the CT ratio<0.85 and tumor size≥3.0cm group (n=5, including three patients with G2 disease) was zero. PNETs with a CT ratio<0.85 and tumor size≥3.0cm should be considered as having a high risk of recurrence after pancreatectomy.