Abstract
Objective: to study some vascular wall stiffness parameters in patients with ankylosing spondylitis (AS) without clinically manifest cardio vascular diseases. Subjects and methods. One hundred and six patients with AS and 21 healthy volunteers without cardiovascular diseases who were matched for age, gender, and cardiovascular risk were examined at two centers. Cardiovascular risk and vascular wall stiffness (augmentation index and pulse wave propagation velocity (PWPV)) were assessed by oscillography. Results. Vascular wall stiffness was comparable in the patients with AS (at both centers) and in the healthy individuals. PWPV was 7.45 (5.4–8.71) m/sec in the AS patients (n = 106) and 8.53 (6.28–9.5) m/sec in the healthy individuals (n = 21); the aortic augmentation in dex was 15.6 (7.9–31.1) and 21.1 (10.2–24) %, respectively; p > 0.05 for all. Correlation analysis revealed associations between aug mentation index, age, blood pressure, disease activity (BASDAI) and spine mobility (BASMI) scores. Conclusion. The vascular wall stiffness did not differ between AS patients without cardiovascular diseases and cardiovascular riskmatched healthy individuals. Its parameters were related to age, blood pressure, and disease activity (BASDAI) and axial skeleton immobility (BASMI) indices.
Highlights
Цель исследования – изучение некоторых параметров жесткости сосудистой стенки у пациентов с анкилозирующим спонди литом (АС) без клинически манифестной сердечно-сосудистой патологии
One hundred and six patients with ankylosing spondylitis (AS) and 21 healthy volunteers without cardiovascular diseases who were matched for age, gender, and cardiovascular risk were examined at two centers
Vascular wall stiffness was comparable in the patients with AS and in the healthy individuals
Summary
Цель исследования – изучение некоторых параметров жесткости сосудистой стенки у пациентов с анкилозирующим спонди литом (АС) без клинически манифестной сердечно-сосудистой патологии. Оценили сердечно-сосудистый риск, жесткость сосудистой стенки (индекс аугментации, скорость распространения пульсовой волны (СРПВ)) методом осциллографии. Жесткость сосудистой стенки у пациентов с АС без сердечно-сосудистых заболеваний и сопоставимых по сердеч но-сосудистому риску здоровых лиц не отличается.
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