Abstract
Intravascular optical coherence tomography (IVOCT) has been employed to clinical coronary imaging for several years. But the influence of flushing and OCT catheter to the blood vessel biomechanical properties have not been studied. In this paper, IVOCT imaging is integrated with the fluid-structure interaction (FSI) simulation to study the blood flow velocity and the stress distribution of a porcine carotid artery during IVOCT imaging. 3D geometric model is built based on the in vivo OCT images, and a hyperelastic model is employed for the material properties of the vascular wall. The blood flow profile and wall stress distributions under various imaging condition are obtained. This study is helpful for the biomechanical property studies of blood vessels and the clinical treatment of vascular diseases.
Highlights
Blood flow and biomechanical properties of vascular wall play a significant role in inducing and modulating physiological responses of endothelial cells (ECs) [Ajami, Gupta, Maurya et al (2017)]
During intravascular optical coherence tomography (IVOCT) imaging, a catheter is inserted into the blood vessel along a guide wire, contrast was injected to optically clear the blood while imaging [Sun, Nolte, Cheng et al (2012)]
3 Discussion and conclusion The velocity profile obtained from IVOCT imaging is integrated with numerical simulation
Summary
Blood flow and biomechanical properties of vascular wall play a significant role in inducing and modulating physiological responses of endothelial cells (ECs) [Ajami, Gupta, Maurya et al (2017)]. During intravascular optical coherence tomography (IVOCT) imaging, a catheter is inserted into the blood vessel along a guide wire, contrast was injected to optically clear the blood while imaging [Sun, Nolte, Cheng et al (2012)]. This procedure may distort the intravascular flow profile from physiological states. During most catheter based interventional procedures, the multiple devices inside the vessel (e.g., guide catheter, imaging catheter, guide wires, etc.) will have already significantly altered the flow profile. The velocity distribution of flushing and structures of vascular wall are simultaneously imaged by OCT, based on which, the stress status of the blood vessel is analyzed
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