Abstract
Viswanathan et al.1 present a thoughtful, timely, and alternative approach to the classification of dementia. Specifically, they stress the importance of vascular factors on Alzheimer disease (AD) and of viewing dementia as a continuum of purely neurodegenerative dementia, purely vascular dementia, and as the combination of both vascular and degenerative contributions seen in some cases. The consideration of other etiologies is also important in the evaluation of dementia. Other diseases may clinically present like AD, including hereditary diffuse leukoencephalopathy with spheroids (HDLS). HDLS is an autosomal dominant …
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