Vascular Parkinsonism: Motor and Non-Motor Response on Treatment with Rotigotine

Abstract

To date dopaminergic therapy has shown unsatisfactory effect on vascular Parkinsonism symptoms and related disturbances. In this case series we describe the effect of rotigotine treatment in patients with subacute onset of Parkinson’s like movement (3-6 months) after ischemic stroke of thalamus or internal capsule areas with concomitant leukoencephalopathy. Rotigotine treatment seems to improve both motor and cognitive symptoms of our sample; further studies are needed to clarify the effect of continuous dopaminergic stimulation on nigro-striatal functions in vascular patients with Parkinsonism like disturbances.