Vascular influences on the dynamic stability of the choledochoduodenal junction.

Abstract

Alterations of arterial, hepatic portal, and central venous pressures are shown to be associated with changes in the same direction of the opening pressures of the canine choledochoduodenal junction. Increases in opening pressures subsequent to increases in vascular pressures could be abolished by the intraductal administration of norepinephrine. Experiments employing the systematic intraductal administration of various pharmacological agents produced data that are interpreted to indicate that alterations in ductal opening pressures are preponderantly dependent in the dog upon local vascular effects.