Vascular endothelial growth factor VEGF and metal-ligand homeostasis in the pathogenesis of ischemic stroke

Abstract

To study the conjugate dynamics of vascular endothelial growth factor (VEGF) and the components of metal-ligand homeostasis in the development of ischemic stroke. The main group included patients with ischemic stroke (n=158). The comparison group consisted of healthy volunteers (n=150). The concentration of VEGF (pg/ml) in the blood serum was determined by ELISA and concentrations of Mg, Cu, Mn, Se, Zn and Fe (mcg/ml) by inductively coupled argon plasma mass spectrometry. Data analysis was carried out using the Statistica 10 application software package and the optimal reliable partitioning (SDR) method, which is part of the Date mining group of data mining methods. A significant increase in the concentrations of VEGF and trace elements Mg, Mn, Cu, Zn, and Se in the blood serum of patients with ischemic stroke was revealed. A significant relationship between the concentration of VEGF and the concentrations of Cu and Mn in the blood serum of patients with ischemic stroke was shown. The dynamics of VEGF and the concentrations of trace elements in the development of the ischemic process contribute to the solution of therapeutic and prognostic problems in clinical conditions.