Abstract
Fibrosis is a common condition, transcending all areas of medicine. Its pathophysiology has eluded researchers for decades with no universal cure. The cellular processes which underpin these conditions begin with cellular proliferation, followed by migration, epithelial to mesenchymal transformation, and extracellular matrix contraction.
Highlights
Fibrosis is a common condition, transcending all areas of medicine
Ischemia, degeneration, or autoimmune inflammatory processes, fibrosis results from proliferation and Trans differentiation of a cellular phenotype to activated fibroblasts known as my fibroblasts
Appreciating the gross variability in both the vascular endothelial growth factor (VEGF) ligand and its receptor, it is the subtleties in this interaction leading to its differential effects
Summary
Faculty of Medical and Health Sciences, University of Auckland, New Zealand *Corresponding author: Matthew McDonald, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand To Cite This Article: Matthew McDonald. Vascular Endothelial Growth Factor Signaling in Fibrosis: An Ophthalmic Perspective.
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