Abstract
IntroductionIdentification of useful markers associated with poor prognosis in breast cancer patients is critically needed. We previously showed that expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful to predict distant metastasis in gastric cancer patients. However, expression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood of breast cancer patients has not yet been studied.MethodsReal-time reverse transcriptase-PCR was used to analyze vascular endothelial growth factor receptor-1 mRNA expression status with respect to various clinical parameters in 515 patients with breast cancer and 25 controls.ResultsExpression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood was higher in breast cancer patients than in controls. Increased vascular endothelial growth factor receptor-1 mRNA expression was associated with large tumor size, lymph node metastasis and clinical stage. Patients with high vascular endothelial growth factor receptor-1 mRNA expression also experienced a poorer survival rate than those with low expression levels, including those patients with triple-negative type and luminal-HER2(-) type disease.ConclusionsExpression of vascular endothelial growth factor receptor-1 mRNA in peripheral blood may be useful for prediction of poor prognosis in breast cancer, especially in patients with triple-negative type and luminal-HER2(-) type disease.
Highlights
Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed
Their findings suggest that vascular endothelial growth factor receptor-1 (VEGFR-1)-expressing cells in the bone marrow or peripheral blood may contribute to cancer metastasis and recurrence
Patient characteristics Blood samples from 25 normal control cases and 515 breast cancer patients were analyzed for vascular endothelial growth factor receptors (VEGFRs)-1 and Ribosomal protein S27a (RPS27A) gene expression levels by quantitative real-time reverse transcriptase (RT)-PCR; expression levels of VEGFR-1 mRNA were corrected for those of RPS27A mRNA
Summary
Identification of useful markers associated with poor prognosis in breast cancer patients is critically needed. No precise markers for prediction of relapse-free survival (RFS) and/or overall survival (OS) in patients with breast cancer have yet been identified. Kaplan et al reported that bone marrow derived cells (BMDCs) expressing vascular endothelial growth factor receptor-1 (VEGFR-1) play an important role in the development of malignant metastasis [3] These investigators showed that BMDCs form a “metastatic niche” in the lungs prior to the arrival of cancer cells, and that blockade of VEGFR-1 prevented this BMDC infiltration and metastatic niche formation. Their findings suggest that VEGFR-1-expressing cells in the bone marrow or peripheral blood may contribute to cancer metastasis and recurrence
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