Vascular Endothelial Growth Factor Levels in Serum of Anaemic Infants and Breast Milk of Their Mothers.

Mohamed Afify,Hend Moness,Salwa Swelam,Christina Kamel

doi:10.21608/mjmr.2022.222880

Abstract

Vascular Endothelial Growth Factor Levels in Serum of Anaemic Infants and Breast Milk of Their Mothers.

Highlights

Aim of work The study aims to estimate the level of vascular endothelial growth factor in the serum of anaemic infants and the breast milk of their mothers
Vascular endothelial growth factor (VEGF) is a polypeptide growth factor that promotes cell survival by inhibiting apoptosis pathway. It increases vascular density through its potent angiogenic property VEGF is known to increase during hypoxia as another compensatory mechanism in the body
VEGF is up regulated by tissue hypoxia, and increased VEGF levels have been used as an early indicator for severe birth asphyxia (Róka et al, 2013)

Summary

Introduction

Anaemia remains the most prevalent nutritional disorder among children in the Middle East and North Africa region. Between 2000 and 2005, the prevalence of anaemia increased from 37.04% to over 52% among Egyptian children between 12 months and 36 months of age. Systemic oxygen delivery depends on cardiac output and arterial oxygen content. Anemic infants have increased cardiac output, echocardiographic measurements are not very useful for determining the need for transfusion. Because arterial oxygen content is determined by the amount and type of hemoglobin, most RBC transfusion guidelines are based on hemoglobin threshold levels. Measurement of fractional oxygen extraction by using near-infrared spectroscopy may be promising, a pilot study failed to identify infants who required RBC transfusion, and serum lactate was considered predictive, values show great variability and added little information to the decision regarding whether to transfuse. Aim of work The study aims to estimate the level of vascular endothelial growth factor in the serum of anaemic infants and the breast milk of their mothers

Subjects and Methods

Results

Discussion