Vascular endothelial growth factor –A (VEGF-A) expression as a prognostic factor in breast cancer

Usharani Rathnam,P P Bapsy,Lepakshi K

doi:10.18231/j.ijpo.2020.018

Abstract

Vascular endothelial growth factor –A (VEGF-A) expression as a prognostic factor in breast cancer - IJPO- Print ISSN No: - 2394-6784 Online ISSN No:- 2394-6792 Article DOI No:- 10.18231/j.ijpo.2020.018, Indian Journal of Pathology and Oncology-Indian J Pathol Oncol

Highlights

Breast cancer is the most common cancer and the leading cause of cancer related mortality in women.[1]
Evidences from literature has demonstrated significant correlation between the VEGF expression in tumor tissue and microvessel density (MVD) in many solid tumors. 3,4 In breast cancer, the MVD has been reported as an important risk factor for metastasis and is associated with poor prognosis. 5,6 there has been lot of interest in exploring the role of angiogenesis in the diagnostic and therapeutic management of breast cancer
VEGF is a potent angiogenic growth factor that acts through receptor mediated pathways and is a potential target for antiangiogenic therapy. 17,18 In this study, we evaluated the association of vascular endothelial growth factor A (VEGF-A) expression with clinicopathological parameters and the survival outcome in 64 breast cancer patients at Apollo Hospital, Bangalore

Summary

Introduction

Breast cancer is the most common cancer and the leading cause of cancer related mortality in women.[1]. 2 Tumor angiogenesis occurs predominantly during the developmental and progression stages of cancer and plays a vital role in metastasis. Evidences from literature has demonstrated significant correlation between the VEGF expression in tumor tissue and microvessel density (MVD) in many solid tumors. Tumor angiogenesis is mediated primarily by vascular endothelial growth factor A (VEGF-A). The study by Hugo Arias-Pulido and colleagues demonstrated an increased risk of breast cancer death and recurrence in patients with high VEGF- A expression at baseline independent of clinico-pathological risk factors and treatment. They concluded VEGF-A expression levels at diagnosis to be an effective prognostic factor allowing individualization of therapy.[9]

Methods

Discussion

Conclusion