Abstract
BackgroundThere is strong evidence that vascular dysfunction is considered one of the possible causes of morbidity and mortality in patients suffering from multiple sclerosis (MS). This work aimed at assessing the arterial function and serum lipids in MS patients and correlating them with clinical and radiological findings.ResultsThis case–control study included 50 patients with MS and 50 age- and sex-matched controls. The arterial function was significantly reduced in MS patients, confirmed by significantly higher pulse wave velocity (PWV) and augmentation index (AIX), while the carotid IMT did not show significant difference between the two groups with no plaques in any of our patients. A significant positive correlation was found between PWV and both disease duration and disability. MS patients had significantly higher serum levels of T-cholesterol and triglycerides, and significantly lower serum levels of HDL-cholesterol, compared to controls. No significant correlation was found between serum lipids and either disease duration or disability.ConclusionsThere was a significant impairment in arterial function (assessed by the brachial cuff-based method via Mobil-O-Graph device) in MS patients compared to controls. Such impairment was significantly correlated with both disease duration and disability. MS patients had also significantly higher levels of T-cholesterol and triglycerides, compared to controls with no significant correlation between serum lipids and either disease duration or disability.
Highlights
There is strong evidence that vascular dysfunction is considered one of the possible causes of morbidity and mortality in patients suffering from multiple sclerosis (MS)
Talaat et al assessed brachial– ankle pulse wave velocity (PWV) and carotid IMT in MS patients. They found that brachial–ankle PWV was significantly higher in MS patients compared to controls (P-value = 0.014)
Soliman et al reported significantly higher serum levels of both Low-density lipoprotein cholesterol (LDL-C) and triglycerides, and significantly lower serum levels of High-density lipoprotein cholesterol (HDL-C) in MS patients compared to controls (P-value = 0.001, 0.02 and 0.01, respectively), but they did not find a significant correlation between lipid profile in MS patients and disease duration or disability
Summary
There is strong evidence that vascular dysfunction is considered one of the possible causes of morbidity and mortality in patients suffering from multiple sclerosis (MS). Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder with recurrent episodes of inflammation, demyelination of the central nervous system and subsequent axonal degeneration [1]. It is considered the main reason of neurological disability in young populations that affects women 2 times more often than men [2]. Inflammation has a major role in atherosclerosis, arteriosclerosis and endothelial dysfunction It enables plaque rupture increasing the risk of acute coronary syndromes [6].
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