Abstract
PurposeTo measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR).MethodsOne hundred seventy six eyes of 94 patients included in this retrospective single-centre cross-sectional study. The subjects were studied in normal, no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative retinopathy (PDR) groups. The eyes were subjected to AngioDisc ONH imaging using OCTA for papillary (Disc) and peripapillary (RPC) vascular density (VD) evaluation.ResultsThe mean age of the participants was 56.08 ± 8.87 years and 34 (36.2 percent) were male. With increased DR severity, a statistically significant decrease in peripapillary VD was found. The study showed that only VD of the whole RPC (W-RPC) could be a valid biomarker in the staging assessment. VD of RPC, in all subsections, was considerably different from normal cases in the PDR group. Visual acuity was correlated with whole image ONH VD. The duration of DM, FBS, hyperlipidemia and DME had no effect on the ONH perfusion.ConclusionsThe study showed that only the W-RPC VD could be a reasonable marker in the staging assessment. VDs assessed by OCTA can be useful for assessing and tracking early ONH changes in DR patients.
Highlights
Diabetic retinopathy (DR) can be a debilitating complication of diabetes mellitus (DM) and is a worldwide leading cause of blindness [1]
Synopsis At the radial peripapillary capillaries, optical coherence tomography angiography basedvascular density is significantly correlated with the severity of diabetic retinopathy anddecreases with its exacerbation
Optic neuropathies that can occur in 38.4% of DR patients include optic disc neovascularization (NVD), diabetic papillopathy (DP), non-arteritic anterior ischemic optic neuropathy (AION), and optic atrophy (OA), and some undefined nonspecific diabetic ONP [3]
Summary
Diabetic retinopathy (DR) can be a debilitating complication of diabetes mellitus (DM) and is a worldwide leading cause of blindness [1]. Diabetic macular edema (DME) and various forms of optic neuropathy (ONP) are other ocular complications of diabetic patients [2]. Optic neuropathies that can occur in 38.4% of DR patients include optic disc neovascularization (NVD), diabetic papillopathy (DP), non-arteritic anterior ischemic optic neuropathy (AION), and optic atrophy (OA), and some undefined nonspecific diabetic ONP [3]. There have been many significant advances in the understanding of the disease over the past few decades, the primary pathogenesis of DR has yet to be identified. DR is characterized by endothelial injury, a leaky blood–retinal barrier, vascular occlusion, and ischemia leading to neovascularization and DR progression [4]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
