Abstract
ABSTRACT Male albino rabbits were injected with 1-thyroxine and physiological saline for 2 weeks. The resulting changes in the aortic wall were assessed grossly and microscopically and also by analysis of hexosamine, hydroxyproline, water, and calcium. Furthermore, the in vivo uptake of 35S sulphate was determined. Despite insignificant gross and microscopic changes, there was a clear-cut increase in hexosamine content and uptake of 35S sulphate, most pronounced in the first part of the aorta, from the aortic valve to the first intercostal arteries, and in the abdominal aorta. These changes were of the same nature as those seen following injections of epinephrine and of epinephrine plus 1-thyroxine. The lesions of the aortic wall might be due to thyroxine induced sensitization to endogenous epinephrine, and the accumulation of mucopolysaccharide probably indicates a reparative process.
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