Vascular changes underlying cerebral lesions in the stroke-prone spontaneous hypertensive rats

Abstract

The relationship of the vascular changes to the cerebral lesions has been studied using serial sections of the brains from five cases of the strokeprone spontaneously hypertensive rats. Infraction was observed in a form of microinfarct related to single or plural occluded arterioles in the brain and subarachnoid space. Though most arterioles with fibrinoid necrosis of the wall were occluded with thrombus, infarct, which was obviously related to the occluded arterioles, was verified only in a few occasions. It was proved that infarction did not develop in all the areas irrigated by the occluded arterioles, and the regional circulation was assumed to have been maintained by the collateral circulation.