Abstract
Vascular changes in early TSH-induced thyroid tumours in the rat.
Highlights
Previous studies (Wynford-Thomas et al, 1982a, b, c, d) concentrating on the pre-neoplastic period have shown that limitation of thyroid growth prior to tumour formation is due to a specific desensitisation of the follicular cell to the mitogenic action of TSH and suggest that the emergence of tumours is due to a failure of this control mechanism
During the course of this work we observed that early tumours appeared to show an increase in vascularity, suggesting that the neoplastic follicular cell might have a trophic influence on capillaries
There was a clear increase in the frequency of follicular cell mitoses in most tumours compared with their very rare occurrence in the background thyroid, which at this stage of ATA treatment is mitotically quiescent (Wynford-Thomas et al, 1982b)
Summary
Previous studies (Wynford-Thomas et al, 1982a, b, c, d) concentrating on the pre-neoplastic period have shown that limitation of thyroid growth prior to tumour formation is due to a specific desensitisation of the follicular cell to the mitogenic action of TSH and suggest that the emergence of tumours is due to a failure of this control mechanism. Each intersection lies at the centre of a small square equivalent to 14.8 pm2 on the section, the mean capillary profile area was given by 14.8 n pm2. For measurement of the surface area of capillary endothelium per unit volume of tissue, (Sv) 12 parallel, spaced, "heavy" grid lines were used for each field, the total line length on the section being equivalent to 1.5mm.
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