Abstract
SummaryBackgroundOsteoarthritis (OA) of the hip is a frequent and debilitating joint disease. Only few clinical risk factors for hip OA are established and clinically applicable biomarkers to identify patients at risk are still lacking. The glycoprotein vascular cell adhesion molecule 1 (VCAM-1) is expressed by chondrocytes and synovial tissue and was a predictive marker for development of severe large joint OA in a previous study.ObjectiveIt was tested whether increased serum levels of VCAM-1 are prevalent in patients with severe OA of the hips.MethodsIn this prospective, multicenter, cross-sectional study, risk factors of severe hip OA were investigated in patients scheduled for hip joint arthroplasty and 100 patients were randomly selected for validation of VCAM-1 as a potential biomarker for hip OA. Serum samples were analyzed by an enzyme-linked immunosorbent assay and compared with a sex and age-matched control cohort.ResultsThe groups were similar in age, gender ratio and prevalence of diabetes. Serum concentrations of VCAM-1 were 8% higher in OA patients compared to controls, without reaching statistical significance (818 ng ml−1, 95% confidence interval, CI 746–891 ng ml−1 versus 759 ng m−1, 95% CI 711–807 ng ml−1; P = 0.4839).ConclusionThe results of this study show that serum concentrations of VCAM-1 cannot distinguish patients with severe hip OA from age and sex-matched controls.
Highlights
Osteoarthritis (OA) is one of the leading causes of disability [1] and affects approximately 15% of the general population aged 15 years and older [2]
Serum concentrations of vascular cell adhesion molecule 1 (VCAM-1) were 8% higher in OA patients compared to controls, without reaching statistical significance (818 ng ml–1, 95% confidence interval, CI 746–891 ng ml–1 versus 759 ng m–1, 95% CI 711–807 ng ml–1; P = 0.4839)
The results of this study show that serum concentrations of VCAM-1 cannot distinguish patients with severe hip OA from age and sex-matched controls
Summary
Osteoarthritis (OA) is one of the leading causes of disability [1] and affects approximately 15% of the general population aged 15 years and older [2]. Vascular cell adhesion molecule 1 in patients with severe osteoarthritis of the hip 369 original article are commonly associated with knee OA [4, 5], but less frequently with hip OA [6,7,8]. Serum VCAM-1 levels were predictive for large joint OA in a prospective study [14] and with knee OA progression in another study [15]. Soluble VCAM1 is proposed as a biomarker for risk prediction of future joint replacement [14, 16]. This study investigated whether serum levels of VCAM-1 are associated with the presence of severe hip OA and compared patients undergoing total hip joint replacement with an age and sex-matched control cohort
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