Abstract
Calcific Uremic Arteriolopathy (CUA) or Calciphylaxis, is a severe morbid and life-threatening condition 1. Ischemic subcutaneous necrosis with vulnerable skin ulcerations are some of the characteristics of this rare but global spread disease. Despite the diagnosis of CUA is clinical, histological confirmation remains the gold standard for definitive diagnosis. Biopsies describe small arteries and arteriolar medial calcification, intimal hyperplasia, inflammation with endovascular fibrosis and microthrombi.
Highlights
Calcific Uremic Arteriolopathy (CUA) or Calciphylaxis, is a severe morbid and life-threatening condition 1
Despite the diagnosis of CUA is clinical, histological confirmation remains the gold standard for definitive diagnosis
The process of vascular calcification was thought to be a passive deposition of calcium-phosphate crystals, the present knowledge suggests cellular activity with differentiation of vascular smooth muscle cells (VSMCs) into chondrocyte as well as osteoblastlike cellular phenotypes and deficiencies in calcification inhibitors [2]
Summary
Calcific Uremic Arteriolopathy (CUA) or Calciphylaxis, is a severe morbid and life-threatening condition 1. Ischemic subcutaneous necrosis with vulnerable skin ulcerations are some of the characteristics of this rare but global spread disease. Despite the diagnosis of CUA is clinical, histological confirmation remains the gold standard for definitive diagnosis.
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