Abstract
In 4 instances of fatal, so-called renal crush syndrome in man, study at necropsy disclosed glomerular ischemia or oligemia; enlargement of the juxta-glomerular apparatus with increased granularity of the cells, hyperplasia and hypertrophy of the afibrillar (granular and non-granular) cells of the media of the pre-glomerular arterioles. In 2 of the 4 cases, intimal granulomata and parietal thrombi were found in the interlobular veins. Since similar changes are found in ischemic (Goldblatt) kidneys, in which the author postulated an endocrino-logic role for the affected cells, consisting of the liberation of a vasopressor substance, it is suggested that similar liberation of a vasopressor substance occurs in the anuric crush syndrome, causing arteriolar spasm at the vascular pole of the glomerular tufts.
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