Abstract
Vascular Aging: Facts and Factors
Highlights
This Research Topic presents a forum of comprehensive reviews on distinct aspects of the pathophysiology of vascular aging to provide insights into the causes and consequences of this complex process and attempts to propose new therapeutic strategies for the management of vascular senescence. Such as the idea proposed by Ming et al (2012) and discussed by Cau and Tostes (2012), which suggests that targeting mTORC1-S6K1 signaling could be a promising therapeutic modality to retard the aging process and treat cardiovascular disease in the elderly
Vascular aging could be described as a consequence of natural physical stress and fatigue that could account for the major physical changes seen in elderly: dilation and stiffening
El Assar et al (2012) present a wide overview of the mechanisms that participate on endothelial dysfunction that accompanies vascular aging, analyzing the synergisms, and interactions between them, some of the cellular mechanisms related to endothelial senescence as well as the prevention or reversion of those mechanisms that produce endothelial dysfunction
Summary
This Research Topic presents a forum of comprehensive reviews on distinct aspects of the pathophysiology of vascular aging to provide insights into the causes and consequences of this complex process and attempts to propose new therapeutic strategies for the management of vascular senescence. Such as the idea proposed by Ming et al (2012) and discussed by Cau and Tostes (2012), which suggests that targeting mTORC1-S6K1 signaling could be a promising therapeutic modality to retard the aging process and treat cardiovascular disease in the elderly.
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