Abstract
Objective: To determine the relationship between vascular age (VA) and endothelial dysfunction (ED) in adults living at more than 3,000 m.a.s.l. Materials and methods: An observational, descriptive, cross-sectional study was performed at the Hospital Regional Docente Clinico Quirurgico Daniel Alcides Carrion, Huancayo - Peru, from January to December 2015. The VA was calculated using the Framingham Risk Score and the ED was evaluated with the flow-mediated dilation (FMD) test in the brachial artery. A p-value <0.05 was considered significant. Results: The study included 67 individuals (100 %), whose mean age was 55.3 ± 13.4 years (range: 30-74), out of which 41 (61.1 %) were women. The VA and the delta value were 57.9 ± 18.3 and 2.3 ± 9.3 years, respectively. Fifty-three point seven percent (53.7 %) (36 participants) had an increased VA and 22.3 % (15 participants) were older than age 10. Increasing age, hypertension and overweight were associated with higher cardiovascular risk. From age 40, VA progressively increases and is more common in men. Individuals with ED presented high cardiovascular risk (87.5 %) compared to those with normal endothelial function (12.5 %) (p = 0.007; OR: 8.52; 95 % CI: 1.7-41.4). There is an inverse relationship between VA and endothelial function (r = -0.437; p = 0.000). The higher the VA , the higher the ED, which is more frequent in men (Rho = -1.0; p <0.010). Conclusions: There is an inverse relationship between VA and ED. Determining the endothelial function could improve the stratification of cardiovascular risk in individuals living at high altitude and thus prevent cardiovascular events.
Highlights
Edad vascular: Es una forma de transformar el riesgo absoluto en otro concepto más entendible por el paciente (5-7,21) y consiste en la edad que tendría una persona del mismo sexo con el mismo nivel de riesgo cardiovascular estimado, pero con todos los factores de riesgo en niveles normales . (5-7,21)
Uso del score de Framingham como indicador de los factores de riesgo de las enfermedades cardiovasculares en la población peruana
Licencia de Creative Commons Artículo en acceso abierto bajo términos de Licencia Creative Commons Atribución 4.0 Internacional
Summary
Edad vascular y disfunción endotelial en personas que viven a gran altura Aníbal Díaz-Lazo* 1,2; Carlos Barrientos-Huamani 1,2. Objetivo: Determinar la relación entre edad vascular (EV) y disfunción endotelial (DE) en personas adultas que viven a más de 3000 m s.n.m. Materiales y métodos: Se realizó estudio observacional, descriptivo, transversal en el Hospital Regional Docente Clínico Quirúrgico Daniel Alcides Carrión Huancayo-Perú, de enero a diciembre del 2015. Hipertensión arterial y sobrepeso fueron asociados con mayor riesgo cardiovascular. Las personas con DE presentaron riesgo alto (87,5 %) en comparación a los que tuvieron función endotelial normal (12,5 %) (p=0,007; OR: 8,52 IC95 % 1,7-41,4). La determinación de la función endotelial podría mejorar la estratificación del riesgo cardiovascular en personas que viven a gran altura y así prevenir eventos cardiovasculares. Palabras clave: Riesgo; Enfermedades cardiovasculares; Endotelio; Hipertensión (Fuente: DeCS BIREME)
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