Abstract
Vasa venarum of the saphenous veins from the patients with associated metabolic disorders
Highlights
At the beginning of the twentieth century it was admitted that the architecture of the vessel wall is structurally dynamic and changes with the growth and ageing
As reference point we used the saphenous vein from the patient with the limb ablation because of the crush syndrome and traumatic injury of the left lower limb who was younger than all the other patients and had no atherosclerosis or diabetes mellitus
We have investigated the vascular architecture pattern in the different layers of the venous wall in correlation with associated metabolic disorders, the microvessel density and the endothelial cell proliferation index using double immunochemistry with CD34 and Ki67
Summary
At the beginning of the twentieth century it was admitted that the architecture of the vessel wall is structurally dynamic and changes with the growth and ageing. From histological and functional points of view, the circulatory system notably manifests itself in specialized microcirculatory beds of organs. This refers to the walls of the veins, which are characterized by a very well developed nutritional system, "vasa venarum" [10]. An example of the practical significance of vasa venarum for the integrity and patency of vessels can be observed in the saphenous veins used as grafts for coronary bypass. The connective tissue that contains microvesels is often removed. This manifests in venospasm [12], which can progress into vein-graft disease and even vein-graft failure [16]. Vasa venarum play an important role in vein relaxation, and any damage of the microvessels during saphenous vein collecting severely affects flow-induced vasodilation of the graft [8]
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