Varying amounts of stretch stimulus regulate stretch-induced muscle hypertrophy in the chicken

Abstract

1. 1. The effects of different amounts of passive stretch per day and number of days of stretch on muscle hypertrophy in the chicken patagialis (PAT) muscle were determined. 2. 2. Stretch for 24 hr per day (h/d) resulted in a more rapid hypertrophy both on a wet and dry tissue basis ( P < 0.001) than stretch for 4 h/d. 3. 3. Stretch increased PAT weight 43% and 25% in 24 h/d and 4 h/d treatments, respectively, after 10 days of stretch, but by day 25 of stretch there was no difference between treatments. 4. 4. In a second experiment, the PAT muscle was hypertrophied and then the effects of intermittent stretch (4 h/d) on regression of hypertrophy (muscle atrophy) were investigated. 5. 5. Intermittent stretch (4 h/d) for 5 and 10 d significantly ( P < 0.001) inhibited regression of hypertrophied muscle. 6. 6. The results of the present study indicate that stretch-induced hypertrophy can be modulated by varying the amount of stretch applied per day. 7. 7. Intermittent stretch can be used to inhibit the regression which occurs when a continuous stretch stimulus is removed. 8. 8. Intermittent stretch is a useful model for investigating mechanisms of muscle hypertrophy and inhibition of muscle atrophy.