Various skin manifestations of mycosis fungoides: histopathological features and prognosis.

Abstract

Mycosis fungoides (MF) is a type of T cell lymphoma, and comprises more than one-half of primary cutaneous T cell lymphomas (CTCL). Many variants of MF have been reported to date, although there are only three descriptions of MF variants in the WHO-EORTC classification published in 2005. Herein, we present four cases of MF, namely classical MF, Woringer-Kolopp disease, bullous MF, and folliculotropic MF. These variants of MF were all typical, although they are quite rare. Their unique clinical manifestations arise from characteristic histolopathological changes in the lesions. The location and amount of infiltrating tumor cells in the epidermis seem to be profoundly correlated with the prognosis.