Abstract
Hyaluronate(HA) is a biopolymer composed of repeating disaccharide subunits of N-acetyl-D-glucosamine and D-glucuronate. HA is extensively distributed in connective tissue, synovial fluid of joints and in vitreous humor of the eye. It has been extensively used as a therapeutic agent in osteoarthritis and ophthalmic surgery. Thus hyaluronate is one of the natural polymers successfully applicable to the biomedical use. The basic properties of crosslinked HA gel have been reported(1) and there are several reports of applying the HA gel to medical devices(2,3). However it is reported that due to the high swelling, the ability of the HA gel to retain other substances is not strong enough to use as a pharmaceutical reservoir(2) Previously we noted the reports that some anionic polymer gels bind cationic surfactants(4,5). We have already reported that dodecyltrimethylammonium bromide(DOTMA) binds HA in solution cooperatively and that the binding constant is much smaller than those of other anionic
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