Abstract
To evaluate the effects for endocrine disruption and the toxic effects on the biomarkers and bioindicators the muddy loach (Misgurnus anguillicadatus) was exposed to endosulfan using a continuous flow-through system for a period of 21 days. This study evaluated the effect of endosulfan using the biomarkers (VTG, AChE, EROD, Comet) and bioindicators (CF, GSI, LSI) should be deleted because it is logically redundant. Male muddy loach exposed to the 2.0 μg/L of endosulfan showed a steep increase of VTG rate compare to the control groups (p 0.05). In conclusion, endosuflan caused vitellogenesis, cytochrome p450 induction, AChE damage and DNA damage in the muddy loach (Misgurnus anguillicaudatus), indicating that those effects should be considered in the case of the EDCs risk aβeβment of the endosulfan especially in benthic freshwater fish. In addition, those biomarkers can be used for the monitoring of endosulfan contamination in aquatic ecosystems.
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