Abstract

The sequential events that cause the airways to narrow have recently been reviewed by Moreno et al.’ and are summarized in Fig. I. The first step in airways narrowing is the activation of airways smooth muscle, followed by smooth muscle contraction and shortening, which reduce the airways lumen and increase airways resistance. The purpose of this article is to summarize these events, emphasizing those most likely to be important as a cause of death in asthma.

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