Abstract
Adams disease is the consequence of overly active transient receptor potential cation channels (TRP). This case report presents a patient suffering from multiple vascular problems and may provide new insights into the causes of venous problems. Endothelial and smooth muscle cells in veins contain TRP. These channels when activated excessively result in calcium accumulation, oxygen radical formation and apoptosis of endothelial and smooth muscle cells. The death of critical cells in vein valves, may lead to varicose veins. The loss of endothelial cells in venules may lead to retinal tears. Damage to vein walls may lead to a deep vein thrombosis. Transient receptor potential cation channels may be new drug targets of interest in the treatment or prevention of these conditions.
Highlights
The cause of varicose veins is not known
This report describes a Caucasian man who suffers from Adams disease that has caused varicose veins in the left leg, a retinal tear in the left eye and a deep vein thrombosis in the left lower leg
Many different forms of transient receptor potential cation channels (TRP) are found in venous endothelial cells and smooth muscle cells [3]
Summary
The cause of varicose veins is not known. About 60% of adults in the US have varicose veins. (2015) Varicose Veins, Retinal Tears and Deep Vein Thrombosis, New Insights into the Causes from Adams Disease. Treatments include various plant derived medicines, compression therapy, sclerotherapy, surgical ligation with stripping, microphlebectomy, and endovenous laser treatment Many of these therapies involve destroying or removing the varicose veins. These clots usually form in deep veins in the legs and are diagnosed with the duplex ultrasound, X-ray venography or magnetic resonance imaging. TRP are the main pain sensing and transmitting receptors in the body and are abundant in skin sensory afferent neurons When these cation channels open, calcium enters into cells.
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