Abstract
The 11-year history of the work that began in 1948 and resulted in the isolation of varicella-zoster virus (VZV) has been published. [1] In 1958, I presented these definitive results along with Witton and Bell. [2,3] By 1983, I was able to review 25 years of progress [4] and to diagram my impression of the natural history of an infection with VZV. I concluded from our findings and the findings of others that the interaction between VZV and its host is a dynamic process. In this paper, I wish to emphasize areas where we presently lack knowledge. First, we have not identified the constraints that limit the growth of virus in vivo. It is now clear that the VZV tissue culture system is an insensitive indicator of virus when used diagnostically, and the bizarre cell-associated growth of the virus remains a frustrating indicator of a basic deficiency of …
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