Abstract
Over a time span of 66 h (sampling time at every 6th hour) the cAMP content in superficial skin punch biopsies of 8 male volunteers (medical students aged 20-30 years) and simultaneously the cAMP level in plasma were measured. By means of autocorrelation (2 alpha less than or equal to 5%) a circadian rhythm in the epidermal cAMP could be demonstrated. Sharp maxima were detected at midnight, whereas minima (not so clearly expressed) were seen at 6 a.m. A variation in plasma cAMP during the day was also established but no significant hint for a circadian rhythm could be found by autocorrelation.
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