Abstract
In this chapter, various findings with respect to barbiturate actions upon drinking are reviewed. It discusses a range of phenomena and classifies those phenomena in terms of variables and models that describe them. The first model is based upon the notion that hypnotic dosage or some function of it suffices to describe the barbiturate facilitation of drinking. A hypnotic dimension of barbiturate action is discussed in the chapter. An implication of simple additivity of effects of various barbiturates follows from the postulated dimension of action that appears to obtain among barbiturate antagonists but not among barbiturate synergists. The finding that various hypnotic barbiturates facilitated drinking to differing degrees necessitated the postulation of at least one dimension of action other than the hypnotic dimension. The chapter discusses the chronic effects and withdrawal after a chronic barbiturate course. When phenobarbital is given with ad lib , food and water intake rise for a very short time and fall rapidly to control levels. Pentobarbital has no effect under these conditions. The withdrawal of phenobarbital results in a marked hypodipsia and hypophagia. A few days after withdrawal, the animals return to a state comparable to controls in terms of food and water intake.
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