Variations in the Volume and in the Acid Content of Gastric Secretion of Normal Individuals Following Stimulation by Histamine

Abstract

Article1 June 1933Variations in the Volume and in the Acid Content of Gastric Secretion of Normal Individuals Following Stimulation by HistamineFRIEDRICH ENGELBACH, M.D., CHARLES L. BROWN, M.D., F.A.C.P.FRIEDRICH ENGELBACH, M.D.Search for more papers by this author, CHARLES L. BROWN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-12-1560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last few years the analysis of gastric contents obtained after stimulation by histamine has come into general use.The work of Bloomfield and Polland1,2 on the acidity of gastric juice following histamine stimulation has shown that the volume and acidity rapidly increase, the maximum being reached in 20 to 30 minutes after injection, after which time the volumes diminish, while the acidity maintains its high level throughout the test of an hour's duration. They found a constancy of response of volume and acid after giving repeated doses of the same amount of histamine to a given individual.Gompertz...Bibliography1 BLOOMFIELDPOLAND ALWS: The diagnostic value of studies of gastric secretion, Jr. Am. Med. Assoc., 1929, xcii, 1508-1513. CrossrefGoogle Scholar2 POLLAND WS: Stimulation of gastric pepsin by histamine, Jr. Clin. Invest., 1932, xi, 449-454. CrossrefGoogle Scholar3 GOMPERTZCOHEN LMW: Further studies on the action of histamine on human gastric secretion, Tr. Am. Gastro-Enterol. Assoc., 1929, xxxi, 28-37. Google Scholar4 KINSELLA VJ: Regional analysis of the stomach contents; a comparison of the cardiac and pyloric curves, Med. Jr. Australia, 1928, ii, 430-433. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication November 11, 1932.†From the Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTiming of Peak Acid Output after PentagastrinEffect of Histamine on Gastric SecretionOn the possibility of reproducing the cephalic phase of gastric secretion 1 June 1933Volume 6, Issue 12Page: 1560-1564KeywordsHistamine Issue Published: 1 June 1933 PDF downloadLoading ...